Glucosamine and Chondroitin: Real or Placebo Effect?

I keep hearing this same information over and over again from reliable sources, I guess it is time to stop spending money on this product.

 (Berkeley Wellness)

Millions of Americans take glucosamine, often with chondroitin sulfate, for the aches and pains of osteoarthritis. Over the years, research has yielded inconsistent findings, but more recent studies have made things clearer.

Glucosamine and chondroitin sulfate are produced in the human body and are involved in the production and maintenance of the cartilage that cushions joints. The supplement glucosamine is manufactured from shellfish; chondroitin, usually from cow bone. It’s claimed that they cure or alleviate arthritis pain, help build cartilage and cushion the joints, and prevent deterioration of cartilage.

What the studies show: In 2006 the government-sponsored Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) reported that neither glucosamine hydrochloride nor chondroitin sulfate, alone or together, reduced pain and other symptoms significantly better than a placebo. (The prescription pain reliever Celebrex, also tested, fared only slightly better.)

But what about the main claim made for these supplements—that they slow or prevent the deterioration of joint-cushioning cartilage that is the hallmark of arthritis? In 2008 results of the second part of the study answered this question. The first GAIT study lasted six months and included 1,600 people with osteoarthritis of the knee, the joint that’s most likely to cause pain and loss of mobility. In the follow-up study, 357 of these subjects continued treatment (glucosamine, chondroitin, both supplements together, Celebrex, or placebo) for an additional 18 months and then had X-ray exams to measure cartilage loss. The exams found insignificant differences in cartilage loss between the groups. Interestingly, glucosamine and chondroitin did worse when taken together than alone, but nothing worked much better than the placebo.





Also in 2008, a Dutch study of 222 people with arthritis of the hip found that another form of glucosamine (sulfate) did not reduce pain or stiffness better than a placebo, and X-rays revealed no differences.

More discouraging news about glucosamine came in July from a well-designed study from Norway. It included people with low back pain and arthritis of the lower spine, half of whom took glucosamine sulfate (1,500 milligrams a day), the other half a placebo. After six months, both groups reported similar levels of disability, pain, and overall quality of life. That is, glucosamine worked no better than a placebo.

Bottom line

Americans spend billions of dollars every year on unproven arthritis remedies including glucosamine. There is no cure, but everything (including a placebo) seems to work at least for some people for a while. The placebo in the GAIT study helped relieve symptoms in a whopping 60% of subjects, about the same as the supplements. Pain relievers help many arthritis sufferers but don’t affect the underlying loss of cartilage. Discuss the options with your doctor. We suggest you forget about glucosamine and chondroitin—unless you are willing to pay $20 or more a month for what is probably a placebo effect. If you already take these supplements and think they help, continue with them, but consider stopping for a while to see if there’s a difference.